Immune adjuvants enhance the body's immune response to antigens, produce stronger immune protection and longer immune memory, and significantly improve vaccine efficacy. An adjuvant is a substance that is formulated as part of a vaccine to enhance its ability to induce protection against infection. Adjuvants are substances added to vaccines to enhance the immunogenicity of high-purity antigens with insufficient immunostimulatory capacity, and have been used in human vaccines for over 90 years. Many vaccines also contain adjuvants or adjuvant combinations: these are substances that are specifically added to vaccines because of their immune-boosting effects. Adjuvants were originally used against the poor immunogenic potential of highly purified antigens. Their role has expanded in recent years as our understanding of the immunology of vaccination has grown.
Global Adjuvant Market Development Status and Future Trends (2016-2027)
Based on QY Research, we estimate that the global adjuvant market size in 2020 will be US$650.24 million, and will reach US$1427.58 million in 2027, with a CAGR of 8.97% from 2021 to 2027.
At the regional level, in 2020, the sales volume of China's adjuvant market reached 2,855 tons, and it is expected to reach 5,802 tons in 2027, with a compound annual growth rate (CAGR) of 9.82%.
In terms of product type and technology, the main products of adjuvant include aluminum salt adjuvant, oil emulsion adjuvant and others. Aluminum salt adjuvant is the most important product type, accounting for 52.55% of the output value in 2020. Aluminum salt adjuvants, including aluminum hydroxide gel and aluminum phosphate, have excellent immune properties and safety, but they also have some drawbacks, such as the inability to generate sufficient antibody responses when used together with small protein molecules with poor immunogenicity Wait. Mineral oil adjuvants mainly refer to adjuvants containing mineral oil components, such as Freund's adjuvant, white oil adjuvant, Montanide ISA206, etc. White oil adjuvant is the most widely used veterinary adjuvant. At present, although the white oil Span adjuvant has some side effects that mineral oil cannot be metabolized, it is irreplaceable in veterinary adjuvants due to its excellent immune effect and cost advantage. Non-mineral oil oil adjuvants mainly refer to oily adjuvants such as vegetable oil and squalene. The current research is most concerned about squalane or squalene, which can improve humoral and cellular immune responses, and has no significant side effects on animals and humans.
From the perspective of product market application, it is mainly human vaccines and veterinary vaccines. Among them, veterinary vaccines are the most important application. In 2020, the proportion of products is 97.62%.
North America is one of the largest adjuvant consumption regions in the world, with sales accounting for 23.81% of the world's total. Followed by Europe, sales accounted for 23.81% of the world.
At present, major global manufacturers include GSK, CSL Limited, Croda, SEPPIC, Novavax, etc. It is expected that the industry competition will be more intense in the next few years.
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