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Single-cell dispensing for automated cell isolation of single cells is gaining increasing attention in the biopharmaceutical industry, mainly for the production of clonal cell lines. Following earlier regulatory guidance issued by the US Federal Drug Administration (FDA) and other regulatory agencies, production cell lines for recombinant products will be cloned from a single progenitor cell in order to minimize population heterogeneity and facilitate isolation and subsequent selection Required for high-yielding clones that might otherwise be overgrown by fast-growing but low-yielding clones. Therefore, single cell cloning is an important step in the production of monoclonal antibodies in biopharmaceuticals. In recent years, with the investment in research and development of monoclonal antibody drugs, the demand for single-cell dispensers has gradually increased.

 

Global Single-Cell Dispenser market size is estimated to be worth US$ 82.95 million in 2022 and is forecast to a readjusted size of US$ 160.17 million by 2028 with a CAGR of 11.59% during the forecast period 2022-2028.

 

Single-Cell Dispenser mainly has two types of microfluidics method and needle selection method according to the screening method. Microfluidic technology enables the cell suspension to be distributed from the dispensing nozzle to the well-plate after passing through the microfluidic channel in the sample reservoir. The Single-Cell Dispenser of the needle selection method uses a needle to aspirate the target single cell and put it into the well-plate.

 

Global key Single-Cell Dispenser manufacturers include BICO, Bio-Rad Laboratories and Sphere Fluidics, etc. BICO is the largest manufacturer, with the revenue share of 46.35% in 2021. The top three companies occupied about 69.07% value share of the market in 2021.

 

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