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Global Lipid Nanoparticles (LNP) Industry Promoted by COVID-19

Author: QYResearch  |   Published Date: 2021-12-21   |   Views: 112

LNPs are liposome-like structures especially geared towards encapsulating a broad variety of nucleic acids (RNA and DNA); and as such, they are the most popular non-viral gene delivery system. Exelead develops and manufactures LNPs to encapsulate different types of genetic payloads including siRNA, mRNA and saRNA.


LNPs are composed primarily of cationic lipids along with other lipid ingredients. These typically include neutral phospholipid molecules belonging to the phosphatidylcholine (PC) class and sterols, such as cholesterol. Another common lipid ingredient is what is known as a PEGylated phospholipid—a polyethylene glycol (PEG) polymer covalently attached to the head-group of a phospholipid.


Solid lipid nanoparticles (SLNs, sLNPs), or lipid nanoparticles (LNPs), are nanoparticles composed of lipids. They are a novel pharmaceutical drug delivery system (and part of nanoparticle drug delivery), and a novel pharmaceutical formulation. LNPs as a drug delivery vehicle were first approved in 2018 for the siRNA drug, Onpattro. LNPs became more widely known in late 2020, as some COVID-19 vaccines that use RNA vaccine technology coat the fragile mRNA strands with PEGylated lipid nanoparticles as their delivery vehicle (including both the Lipoid and the Pfizer–BioNTech COVID-19 vaccines).


Market competition is intense with high technology barrier. Merck KGaA, Exelead, Avanti Polar Lipids, Nippon Fine Chemical, Genevant Sciences, etc. are the leaders of the industry, with high-end customers. The top five manufacturers held 76.24% of the market, in terms of Lipid Nanoparticles (LNP) revenue in 2020.


According to QYResearch latest research, the global Lipid Nanoparticles (LNP) size is estimated to be USD 829.68 million in 2026 from USD 104.25 million in 2020, with a change 459.44% between 2020 and 2021. The global Lipid Nanoparticles (LNP) market size is expected to grow at a CAGR of 7.3% for the next five years.


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