Bruton’s Tyrosine Kinase (BTK) Inhibitors Market Highly Concentrated with only Several Players Engaged

Bruton’s tyrosine kinase (BTK) is a key component of the B-cell receptor (BCR) signalling pathway. BTK is an important protein that is a regulator of cell proliferation (growth) and cell survival in various B-cell lymphomas & CLL.

Bruton's tyrosine kinase (BTK) inhibitors work by binding to the BTK protein. BTK inhibitors block this protein's activity by the BCR-induced BTK activation and its downstream signalling. BTK inhibitors block the activity that leads to growth of the B-cells and this causes cell death of the malignant B-cells.

The BTK inhibitors may help move abnormal cells out of their nourishing environments in the lymph nodes, bone marrow and other organs where it gets excreted. BTK is also found in normal healthy B cells so this action of blocking may cause side effects.

This class of drugs have had great success in recent years for many different subtypes of indolent lymphoma and CLL/SLL, both as a single (monotherapy) or in combinations with other medicines.

BTK inhibitors are highly concentrated with technology barrier. Johnson & Johnson, AbbVie, AstraZeneca, BeiGene, INNOCARE, Ono Pharmaceutical. are the only engaged players of the industry presently. The five manufacturers held 100% of the market, in terms of Bruton’s Tyrosine Kinase (BTK) Inhibitors revenue in 2020.

In 2021, the global Bruton’s Tyrosine Kinase (BTK) Inhibitors market size will be US$ 9068 million and it is expected to reach US$ 21926 million by the end of 2027, with a CAGR of 15.85% during 2019-2027.

Bruton’s Tyrosine Kinase (BTK) Inhibitors is widely used for CLL/SLL, WM, MCL, FL, RA, SLE, etc.

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